Rheumatoidarthritis, adisablingdiseasethatcaninflameanddeformmultiplejoints, mayoriginateinthelungs, accordingtoresearchpublishedinArthritis & Rheumatism. Elevatedlevelsofrheumatoid-arthritisantibodieshavebeenfoundinpatientsbeforetheappearanceofjointsymptoms, suggestingRAhasanearlypreclinicalphase, researcherssaid. LungdiseaseisalsoassociatedwithearlyRA.
呼吸道和关节炎：根据《关节炎与风湿病》（Arthritis & Rheumatism）期刊发表的一项研究，会引起多个关节发炎和变形的致残疾病风湿性关节炎可能源自肺部。研究人员说，在关节出现炎症前就已经发现病人体内风湿性关节炎抗体水平的提高，这表明风湿性关节炎存在较早的临床前阶段。肺部疾病也与初期风湿性关节炎存在关联。
Thestudyexaminedairwayabnormalitiesin 69 patientsfromDenverandLosAngeles, 42 withRAantibodiesandnojointsymptoms, 15 withnoRAantibodiesorjointsymptoms, and 12 withearlyRA. Alltheparticipantsunderwentlung-functiontestingandCTlungimaging. Pain, stiffnessorswellingwerereportedinatleastonejointby 50% ofantibody-positiveand 53% ofantibody-negativesubjectsatthetimeofimaging. Ofthe 12 withRA, threehadbeenpreviouslydiagnosedwithasthmaandthreewithemphysema.
这项研究对来自丹佛和洛杉矶的69名呼吸道异常的患者进行了检查，42人有风湿性关节炎抗体但无关节炎症状，15人无风湿性关节炎抗体也无关节炎症状，12人患有初期风湿性关节炎。所有患者都进行了肺功能检查和肺部CT显像。在肺显像时，50%抗体呈阳性者和53%抗体呈阴性者表示至少有一处关节有疼痛、僵硬和肿胀。在有风湿性关节炎的12人中，三人以往曾被诊断有气喘，三人被诊断有肺气肿。
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